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The first DET physician prescription date was designated as the index date.
The first GLA physician prescription date was designated as the index date.
For timed matings, noon of the plug date was designated E0.5.
Conception date was designated as the day a vaginal plug was observed.
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The vaginal plug date is designated as embryonic day 0.5 (E0.5) following convention.
Genotype, site and sampling date were designated as fixed effects and block and sampling date as random effects.
In a landmark analysis, a period of time between a baseline date (cohort entry) and a study start date (the landmark date) is designated the exposure period and chosen a priori.
Twelve months prior to the index date and 12 months after the index date were designated, and only patients with a full 2 years of medical and pharmacy benefits during this period were retained for both cohorts.
The date of NSI was designated as the index date for each case control set.
The date of birth was designated as the day pups were observed.
Date of birth was designated as postnatal day P0.
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