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Calculations of LTFU rates were therefore based on patients who started ART at least nine months before the closure date of the database.
Patients were considered lost to follow-up if their last visit preceded the closure date of the database by nine months or more and no death had been recorded by that time.
The administrative censoring date of the database is 31 March 2008.
Searches, using the strategy listed in online supplementary appendix 1, will start from the start date of the database through to September 2015.
We considered a patient as lost to follow-up if their last visit preceded the closure date of the database by 6 months and if he was not dead and had not been transferred to Vientiane.
However, patients whose first myopathy event was within the first 6 months of the database were excluded; we could not rule out additional myopathy events prior to the starting date of the database (01/01/2004).
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Potential relevant published studies were identified from the databases Medline, Embase, Chemical Abstracts and Biosis (from starting date of the databases until March 2009).
The entry date of 1 January 2006 was selected because it was midway between the start of pioglitazone marketing in Taiwan (2002) and the end date of the databases (2009) and provided a maximum exposure of 4 years and a maximum follow-up of 4 years.
Repair in this case involves getting a correct and up to date copy of the database, without halting the two operational nodes.
We systematically searched the following four databases for articles published between the inception dates of the databases and March 2013: MEDLINE, Embase, CINAHL and Cochrane Central Register of Controlled Trials.
The last update date of the ICT database and the date and version used for each resource should be clearly communicated to the user e.g. via the manuscript, app and/or ICT website.
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