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20 For this study, we excluded women with no information on the date of the consent agreement (n=34), women who entered the cohort after 22 weeks of pregnancy (n=1661), women with no information of the date of the pregnancy outcome (n=81) and women with ectopic pregnancies (n=66) or mola hydatidosa (n=48).
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OS2 was defined as the time from the date of the informed consent until the date of death from any cause.
Progression-free survival (PFS) was defined as the length of time from the date of the informed consent to disease progression or death from any cause.
One PFT per participant was chosen, with the test performed closest to the date of consent to the registry selected for inclusion in the analysis (12/2004-9/2010).
Overall survival was measured from the date of consent to the use of vinflunine to the date of death from any cause.
Progression free survival was measured from the date of consent to the use of vinflunine to either the date of first objective evidence of disease progression or date of death, whichever occurred first.
The study design means that patients will spend variable amounts of time in the study depending on the date of signing the informed consent form, the length of the enrolment period, and the date of their index episode.
Adverse events and concomitant medications were recorded on an ongoing basis from the date of consent until the final visit.
The duration of PHN was defined as the number of months between the PHN start date and the date of informed consent.
PSA values were available up to the date of consent, and during the 72-week study follow-up for the vaccinated cohort; ethical permission to collect time-point-matched PSA values for the unvaccinated patients was not obtained.
Progression-free survival was calculated as the interval between the date of signing informed consent and the date of disease progression, or death from any cause.
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