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Each participant who switched to Respimat was matched at the date of switching (index date) with one control patient.
Individuals switching from ACEI to ARB therapy or from ARB to ACEI therapy during follow-up were censored at the date of switching, as there have been suggestions that the protective affects of ARBs and ACEIs may persist for years after stopping treatment [ 18, 19] (see Figure 1).
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The date of switch was the date of the first new maintenance treatment claim.
12 For each switch in ART, the hospital pharmacist recorded the patient's data, date of switch, reason for switch, previous ART, and new ART.
In these analyses, all patients start as non-switchers; if the patient switched modality the patient then became a switcher on the date of switch.
We examined the data for these subjects up to 18 months after ART initiation or at the date of switch to a second-line ARV regimen.
Patients were followed from index until one of the following events occurred: (1) date of discontinuation (run-out date of the last prescription filled prior to a 30-day gap in therapy), (2) date of switch to another atypical antipsychotic, (3) end of the follow-up period (6 months or 12 months), or (4) occurrence of outcome (hospitalization or ER visit).
However, to date, few data have been reported on the outcome of switching patients between these two treatments.
The date of therapy switching was assumed to be the date of first receipt of the new antipsychotic.
Due to the nature of our data, it was also possible to examine when, relative to the date of admission, switches were performed, and the prevalence of different switching methods.
Data from patients who elected to switch to alternative MS treatment (not those who discontinued study medication without switching to another disease-modifying therapy) were censored as of the date of the switch.
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