Date of first death in the family.
bFrom date of referral to date of first visit.
**Days from date of first recruitment.
Date of second submission: 3.09.2014.
Finally, registration dates and dates of first enrolment were compared.
Duration of clinical development (from initiation of studies in humans to receipt of Marketing Authorisation), subdivided into clinical trial and regulatory approval periods by the date of Marketing Authorisation Application.
5 This period was further subdivided by the date of Marketing Authorisation Application (MAA, regulatory submission or 'filing') into periods representing clinical trials (prior to filing) and subsequent regulatory approval.
The index date was defined as the date of the first triptan prescription.
The date of the first diagnosis claim was designated as the index date.
For each case, the date of the first diagnosis was assigned as the index date.
Table 1 summarises when the products were originally licensed, the date of the latest authorisation and the date of the most recent substantive change to the SPC.
