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Although the use of efflux pumps inhibitors (EPIs) represents a promising strategy to reverse resistance, to date few M. avium EPIs are known.
Moreover, the relevant and hidden role of efflux pumps in the intrinsic levels of azithromycin resistance is highlighted, showing the potential clinical utility of efflux pumps inhibitors.
It is important to note that we observed a correlation between efflux mutations and relative fitness that is likely explained by reduced fitness resulting from the cost of overexpression of efflux pump s 39.
Some species of bacteria have several types of efflux system.
Count of efflux value per bin versus efflux value.
Another possible mechanism is through the disruption of efflux kinetics.
Efflux of bile salts from bacteria is mediated through a number of efflux systems.
However, QS regulation of efflux pumps may have other consequences.
Date of publication: July 2013 .
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