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To control for possible confounding effects of physical illness other than COPD, we retrieved data on previous hospitalisation for other physical illness from the NPR, excluding pregnancy and childbirth, mental and behavioural disorders and external causes (including accidental and intentional poisonings, and injuries), prior to the time of suicide or the matching date of control (index date).
In some articles (Hepworth et al. 2006; Schoemaker et al. 2005), controls were allocated into categories of interview lag time at random without consideration of age and sex of the cases within these categories, whereas in others (Lönn et al. 2004a), average lag between diagnosis and identification in a matched set was subtracted from date of control identification.
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As some myeloid malignancies, particularly MDS and MPD, can be chronic conditions, we conducted additional analyses excluding the 2 and 5 years before the diagnosis date of cases and the selection date of controls to ensure that the autoimmune conditions preceded MDS and MPD.
The dead cases will be matched with two different sets of controls: two general population controls who were alive at the case's date of death (Controls B), and one diseased control who was alive at the case's date of death and had had invasive primary breast cancer (screen-detected, interval and never screened will all be included) at the case's date of first diagnosis (Controls E).
The index date of the control patients was randomly assigned based on the distribution of index dates of SLE patients.
The results are in agreement with the previous study by Vasquez-Prokopec et al. [ 46], showing that variation of the start date of vector control had a major impact of the overall scale of the simulated outbreaks.
The risk factor status of both cases and controls was updated from the questionnaire most recently completed before date of diagnosis (controls were assigned the date of diagnosis of their matched case).
Cases were matched to surgeon, gender, body mass index, age, and date of surgery controls (n = 20) who underwent primary unilateral TKA without developing VTE before patient discharge.
The index date of the controls was set to be that of the case (i.e. the start of the exacerbation episode).
The index hospitalization date of the controls was limited to be within the same year as that of their matched cases.
The difference in average date of participation (controls) vs. average date of diagnosis (cases), which determined when exposure assessment ceased, was less than 6 months (Table 3). 1 cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 10 10, as rating-year.
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