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We used the hospital admission date of cases to calculate the exposure windows for controls.
As some myeloid malignancies, particularly MDS and MPD, can be chronic conditions, we conducted additional analyses excluding the 2 and 5 years before the diagnosis date of cases and the selection date of controls to ensure that the autoimmune conditions preceded MDS and MPD.
PERCH ultimately decided to enroll community controls and an additional human immunodeficiency virus (HIV infected control group at high HIV-prevalence sites matched on age and enrollment date of cases; controls with symptoms of URTI or nonsevere pneumonia will not be excluded.
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To date (February 2014), no further cases caused by the L. monocytogenes SV1/2b cluster strain have been reported since 15 July 2013 (hospitalization date of case 7).
*Cases and controls were considered vaccinated with two doses if the most recent dose was administered ≥14 days before date of case's hospital visit.
The date of case diagnosis indicated that the strain had been circulating since April 2003 in 5 districts of northern France before the outbreak was recognized (Table 1).
Smoking status and alcohol intake were recorded at 1 year prior to the date of case diagnosis (or closest record prior to this).
Educational years and tobacco and alcohol use were obtained by self-report from the subject prior to the index date of case or control determination.
Cases and controls were only enrolled if they were resident in their municipality from at least 2 years before the date of case diagnosis or from the screening programme start date.
The median duration of exposure data available prior to the date of case diagnosis was 4.8 years for cases (range 1.0 12.4 years) and 4.4 years for controls (range 1.0 12.5 years).
*Cases and controls were considered vaccinated with respective number of doses (one, two, or three) if most recent dose was administered ≥14 days before date of case's hospital visit.
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