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For cases, this was the date of breast cancer diagnosis.
The date of breast cancer diagnosis served as the index date for women in our cohort.
We obtained information up to the date of breast cancer diagnosis.
Third, we studied the time between the start of 5-ARI exposure and the date of breast cancer diagnosis.
Overall survival was the time between the date of surgery and date of breast cancer death or last follow-up.
We calculated person-years from the baseline questionnaire to the date of breast cancer diagnosis, death or December 31 , 2005 whichever was sooner.
Furthermore, because the prescription records antecede the date of breast cancer recurrence, they are a prospective data source presumably immune to differential classification bias (Rothman et al, 2008).
The exposure period in the controls was of the same duration as their matched cases starting from the date of breast cancer diagnosis.
The underlying time variable in the analysis was time from the date of cohort enrollment to the date of breast cancer diagnosis, death, or censoring.
The database provides detailed information on the type and date of breast cancer recurrence and the date of last follow-up.
Observation time was calculated from date of entry into the cohort until the date of breast cancer, emigration, death or 31 December 2005, whichever came first.
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