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Follow-up was defined as complete if patients' medical files were up to date (last contact with the hospital between December 1, 2004 and June 1 , 2005.
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The hospital tumor registry was also the source of follow-up information; the registry conducts active follow-up for each patient, contacting the physician or the patient annually and recording the date last contacted and the vital status.
We created a report of the HIS form to extract follow-up information (initial diagnosis date, initial therapy date, date of last contact, status at the last contact, etc).
Name, sex, date of birth, state, date of last contact, and date of death (if available) were used to match participants to the NDI.
Overall survival was defined as the time period between date of diagnosis and the date of death or date of last contact if exact date of death is unavailable.
Survival was calculated from the date of diagnosis as well as from the first date of cetuximab treatment to the date of last contact or to the date of death from any cause.
We defined survival time (in months) as the time from the date of diagnosis to the date of death or the date of last contact.
Overall survival was calculated by subtracting the date of death or date of last contact from the time of the initial diagnosis.
The variables recorded for survival analysis included the date of diagnosis, the date of last contact and vital status (alive/deceased).
Follow-up was calculated from date of study enrollment until date of last contact.
OS was defined as the duration between the date of diagnosis and the date of last contact.
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