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RE ANNOTATE processes the similarity annotation to infer the common origin of dispersed repetitive sequences, resolve complex nesting patterns, and date insertion events LTR-elements with a detectable structure.
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Catheter and localization, the use of ultrasound, date of insertion and removal were collected, major bleeding, pneumothorax, and catheter bacteremia.
There were 35 undetermined elements with 100% LTR similarity and their average date of insertion was 3.1 Mya.
The outcome of interest was "time to first revision", being the time interval between the date of insertion of the primary prosthesis and the date of revision.
Despite these biases, this approach has been widely used [ 29, 30] and provides useful information about the date of insertion of each copy.
There was only 1 Gypsy element with 100% LTR similarity and the average date of insertion for these elements was 4.1 Mya.
The registration of the date of insertion of the VLs improved significantly between the first and the second studies (42.3 % vs 50.1 %; p < 0.001).
If the substitution rate is known, then the date of insertion can be estimated from the amount of divergence between the two LTRs [ 16].
The ability to date retrotransposon insertion times (SanMiguel et al. 1998) provides an independent mechanism to verify our classification of parental and recombinant elements.
The attending nurses were interviewed and a series of data was recorded (date of insertion of each VL, registry of daily surveillance, date of last dressing change, and date of last administration set replacement).
Full-length retrotransposons were analysed by comparing their 5' and 3' LTR sequences in order to date their insertion time [ 65] based on the assumption that the two LTRs of a single element are identical at the time of insertion.
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