Sentence examples for date has established from inspiring English sources

The reduction in breast cancer incidence seen in the tamoxifen arms of the four prospective trials to date has established the proof of principle that antagonizing estrogen is a potential means of reducing breast cancer risk.

In the meantime, says Rilling, we have to keep his findings in perspective: testosterone is just one influence among many on men's behavior, and his research to date has established correlations, not causations.

Despite knowledge of RFRP's responsiveness to stress and its role in regulating reproductive axis activity, no study to date has established a causal link between RFRP and fertility in any species.

Although no study to date has established a link between poor INR control and health outcomes in LTC, warfarin-related adverse events are common in the LTC facility: the combined overall rate of adverse warfarin-related events and potential adverse warfarin-related events was high, equivalent to one adverse effect for every 4 months on therapy [ 25].

Hoping that direct interaction with customers may raise customer relationships to the next level, more than 100,000 companies to date have established brand pages on social media platforms such as Facebook.

Few studies to date have established the empirical relationship between monthly weather and mortality in sub-Saharan Africa.

Nonclinical examination and clinical trials to date have established the antitumor efficacy of lapatinib against HER2-expressing cancer while that against EGFR-expressing cancer is limited.

However, few studies to date have established acute responses to flavanones, and thus the potential mechanisms for a cardiovascular benefit remain unclear.

While studies to date have established TMEM106B as an important risk factor for FTLD-TDP and implicated TMEM106B in progranulin pathways, many basic features of this protein -- including its expression patterns in human brain -- are largely unknown.

DOI: http://dx.doi.org/10.7554/eLife.03650.012 Our studies to date have established LapDG as an efficient signaling node to control cell adhesion and biofilm formation (Newell et al., 2009; Navarro et al., 2011; Newell et al., 2011a; Newell et al., 2011b).

Radiocarbon dating has established the dates of three of Mount Tambora's eruptions before the 1815 eruption.