Sentence examples for date has been demonstrated from inspiring English sources

No mortality benefit to date has been demonstrated.

MiR-34a is highly upregulated following p53 activation [Chang et al., 2007; Hermeking, 2007] and to date has been demonstrated to be involved in: (a) cell cycle arrest in the G1 phase; (b) induction of cell senescence; and (c) apoptosis [Chang et al., 2007; He et al., 2007; Hermeking, 2007].

Most of the Rf genes (nuclear-encoded genes responsible for fertility restoration of CMS) identified to date have been demonstrated to encode a PPR protein [ 25, 41- 48].

To date, it has been demonstrated that intracellularly expressed affibody molecules can bind to target molecules and inhibit their functions.

Although only limited studies have concerned DNA adducts in human sperm to date, it has been demonstrated that PAH-DNA adducts in sperm are correlated with abnormal sperm morphology, decreased sperm count, declined progressive motility and impaired fertilization during ICSI (intracytoplasmic sperm injection) [13] [16].

To date, cortactin has been demonstrated to be essential for the development of disease by numerous bacterial pathogens.

To date, MRI has been demonstrated to be valuable in the characterisation of pelvic floor muscle defects [ 7, 8].

To date, it has been demonstrated that the RA signaling plays sophisticated roles in early embryonic development.

To date, insulitis has been demonstrated in two of three non-diabetic donors with multiple autoantibodies but not in any of the 18 donors with a single autoantibody.

SaPIov2 encodes a novel allelic variant of the vWbp encoded in the chromosome of all S. aureus strains examined to date, which has been demonstrated to have coagulase activity for human and rabbit plasma (Bjerketorp et al. 2002).

To date, it has been demonstrated that the promoter region of the PHD3 gene is hypermethylated in plasma cell neoplasia, prostate, melanoma and mammary gland cancer cell lines [ 12, 13].