Earlier year at index date for regimen initiation and substance abuse were associated with a greater risk of discontinuation.
All other trials began enrolling prior to 1 July 2005, the cut-off date for the initiation of the requirement by the International Committee of Medical Journal Editors for trials to be registered, so are not associated with any public database identifiers.
Patient covariates included age, sex, geographical region (Northeast, Midwest, South, West), total daily pills of non-ARV treatment, Charlson Comorbidity Index scores, calendar year at index date for regimen initiation, and psychiatric and substance abuse comorbidities per corresponding ICD-9 diagnostic codes.
For those born after June 1986, the date of initiation of coverage for all newborns, the seropositive rate among Taiwanese women even decreased into 3.1% while the rate in women from the five other countries was 28.6% and the odds ratio was 12.4 (95% CI: 1.67 91.9) with p-value of 0.04.
Of the HIV-positives, 192 were HAART-naïve at enrollment but initiated HAART while participating in the REACH study; 62 started HAART on the first visit and lacked before HAART initiation follow-up; 22 had missing dates for the initiation of HAART; and seven lacked adequate follow-up data after HAART initiation.
The date of initiation of treatment for each patient was defined as the date of RC or the date of initiation of NAC for patients who received NAC.
For each case the following timelines were determined: date of symptom onset, date of first presentation to medical care, date samples were taken for viral testing, and date of initiation of antiviral drug treatment.
The main potential confounders were age at study entry, sex, use of any class of OHA after inclusion, and information on duration of diabetes, which was estimated from the date of initiation of the ALD for diabetes (when available).
Follow-up: Date of disease progression (if patient is withdrawn for reasons other than progression), Date of initiation and type of any second and subsequent lines of therapy, Date of death.
Date of disease progression (if patient is withdrawn for reasons other than progression), Date of initiation and type of any second and subsequent lines of therapy, Date of death.
