Sentence examples for date alterations from inspiring English sources

To date, alterations within the DNMT1 gene have not been reported to be associated with cancer in the Caucasian population.

To date, alterations and activation of the PI3K/AKT pathway are well established in the initiation and progression of extracranial human BC [ 6, 8- 14, 15, 15].

To date, alterations of the Akt/mTOR pathway have been observed in numerous types of carcinomas, but little has been reported about Akt/mTOR signaling in skin tumors.

Although to date such alterations are poorly understood, they may have important implications for teratology.

To date, genetic alterations of TCEAL4 in human cancers have not been described.

To date, epigenetic alterations appear to be the most likely mechanisms that could explain perinatal programming leading to later-life obesity and metabolic diseases (Barouki et al. 2012).

To date, genetic alterations associated with remnant gastric cancer have included p53, Ki-ras, cyclooxygenase-2, and bcl-2 (Clarke et al, 1997; Yamashita et al, 1998; van Rees et al, 1999; Baba et al, 2001; Kawabe et al, 2002).

To date, biochemical alterations have been reported in the growth hormone-insulin-like growth factor axis (GH- IGF) in African Pygmy populations (Bozzola et al. 2009; Jain et al. 1998; Merimee et al. 1981; Rimoin et al. 1969).

For kinases, allosteric mechanisms described to date include alteration of protein kinase conformation blocking productive ATP binding which appear 'ATP competitive' or blocking kinase activation by conformational changes that are 'ATP non-competitive'.

The database collates information from a wide range of scientific studies that document significant environmental changes such as diminishing glaciers, melting permafrost, earlier snowmelt, lake and river warming, and coastal erosion as well as changes in biological systems such as earlier leaf unfolding and blooming dates and alterations in species interactions.

However, in controlled environmental chemical exposures to date, only partial alterations of fish sexual phenotype have been observed.