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To date, all reports have suggested that RTS,S/AS is well tolerated and has a good safety profile.
To date, all reports of acquired UPD in solid tumors have been in association with the "two hit" inactivation of tumor suppressor genes [9], [11], [16].
Up to date, all reports (including ours) focusing on genetic predisposition to life-threatening events in cirrhotic patients are prone to interpretation bias related to low power analyses, a limitation that will not be overcome until coordinated work of international research consortia allows the establishment of large cohorts of patients.
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To date, all reported cases have been associated with germline mutations of the SDH genes.
To date, all reported potential pathogenic mutations in ASXL3 have been either frameshifting or truncating [ 23].
To date, all reported cases have been associated with the use of artesunate not produced under Good Manufacturing Practice (GMP) standards.
By contrast, to date, all reported incidences of sirenomelia in humans have been sporadic cases (Castilla et al., 2008; Thottungal et al., 2010).
To date, all reported mutations are located in the IDH1 and IDH2 genes and result in an amino-acid substitution at residues located in the enzymatic active site, respectively, R132 for IDH1 and R140 or R172 for IDH2.
To date, all reported cases have been attributed to mutations in galactosylceramidase gene (GALC gene) that encodes an enzyme which degrades galactosyl-sphingolipids (galactosylceramide, psychosine), essential in myelin production.
To date, almost all reports of infection or colonization with ESBL- and plasmidic cephamycinase-producing E. coli (i.e., extended-spectrum cephalosporin-resistant E. coli [ESCREC]) have involved hospitalized patients or nursing home residents (3, 6 ).
To date, all the reported CNV analyses in D. melanogaster were based on heterogeneous isofemale strains from natural populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com