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All datasets will be analyzed separately and the results of the 20 analyses will be pooled using Rubin's rules [ 36].
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Data will be analyzed on an intention-to-treat basis following CONSORT CLUSTER criteria to avoid bias by incomplete datasets.
Keeping in mind that each file will be analyzed using small windows, and that each window will be classified as singly or doubly encoded, we generated the training dataset as follows: 1.
(This will be analyzed later).
Other researchers will be analyzing economic data.
This dataset will not be analyzed in detail here.
To solve this issue, three different datasets will be provided in future editions: training dataset, development dataset, and test dataset.
36 Ten imputed datasets will be created.
Expression datasets will be deposited at geodatasets.
Five to eight versions of the final analysis dataset will be created and analyzed using identical procedure, followed by combining the results so that variation between imputation versions is incorporated in the standard error and p-value.
Additional datasets will need to be analyzed to further study these substitution patterns and the way they differ among protein-coding genes.
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