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The datasets were replicated by randomly sampling from the actual data (sample subject ID with replacement of up to the total number of subjects in the original dataset).
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The additional datasets are replicated experiments measuring alteration of the transcriptome through response variation within a single genotype [Development; [33]) and by abiotic stress (Abiotic; [34]].
Each dataset was replicated 100 times, and the last consensus tree was decided by majority rule with Consense in the PHYLIP package [ 59].
In four of these, training dataset findings were replicated in the validation dataset.
These observations were replicated in both datasets and could be detected (and replicated) in individual subjects from the HCP.
Moreover, linkage results for camptothecin-induced cytotoxicity were replicated across multiple datasets.
These findings were replicated in another case-control dataset.
Furthermore, the predicted probability of LN involvement was negatively associated with age in each subgroup (Figure 3A) in the first dataset, which was replicated in the second dataset (Figure 3B).
30 Given the extensive list of patient and surgical variables considered for inclusion in the model, we wanted to ensure that we minimised the possibility of making a type 1 error (rejecting the null hypothesis when it is true)—for example, the chance that a variable identified as being 'significant' in this dataset may not be replicated in other samples of patients.
This has been illustrated previously in this dataset [ 11] and is replicated in Figure 2.
Each simulated dataset and model analysis was replicated ten times for limitIBD of 0.75 and 0.95 and all four window sizes, while in total 52 replicates were considered for limitIBD of 0.55 and all four window sizes.
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