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Datasets were obtained using the Stanford Research Institute SRI PathWay tools [32] and by later curating the database with Arabidopsis-rice ortholog annotations.
These datasets were obtained using Roche 454 FLX and Sanger sequencing with two different libraries (shotgun and fosmid).
Estimated nucleotide substitution rates and MCC trees for both the VP60 and RdRp datasets were obtained using BEAST v1.5.4 [ 64].
All three datasets were obtained using the Affymetrix HGU133A or HGU133 Plus 2.0 platform; thus they were highly comparable.
Gene datasets were obtained using a variety of strategies, including RNA-seq, homology and ab initio gene prediction.
Microarray expression data from various datasets were obtained using Genevestigator (https://www.genevestigator.com/gv/) with the tomato Gene Chip platform.
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The 3D structures of the 14504 ligands in the Borodina dataset were obtained using the PubChem Download Service (using the PubChem Substance IDs from Borodina et al).. Of these, 16 could not be handled by the MMFF94 forcefield, 5202 had no rotatable bonds (this fraction included a large number of trivial salts) and 2348 had more than 1 million conformers (according to Confab's torsion rules).
Transcript mapping and abundance estimation for each sample in the dataset were obtained using bowtie v0.12.7 [ 49] and RSEM v1.2.8 [ 57].
For Manesh215, the values of ASA in Manesh215 dataset were obtained using the ASC program [ 49] with van der Waals radii given by Ooi et al. [ 50].
In the image quality assessment configuration, the dataset is obtained using eight different databases, according to two different setups.
Diameter inside bark along the bole for each tree in the held-out dataset was obtained using the fixed effects parameters of the fitted taper equation.
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