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The classification accuracies of these datasets were obtained by k-fold cross-validation.
The point cloud datasets were obtained by TLS at three different times in 2011, 2013 and 2014.
The datasets were obtained by an elastic 3D FDTD modelling approach for the actual field acquisition geometry and the most realistic model of the subsurface and distribution of elastic properties in the gas plume.
The signals from each array element attributed to the sequential-ChIP experimental datasets were obtained by subtracting signal for each sequential ChIP control from the sequential-ChIP values in the ChIP channel.
These datasets were obtained by the following procedure.
The true clusters for these datasets were obtained by aligning the reads with Bowtie against the Arabidopsis reference genome while allowing up to three mismatches in the alignments.
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On the other hand, when the nucleotide misincorporations originated from an underrepresented A and T nucleotide, their values were multiplied by the ratio G+C/A+T in the specific fragment The total number of the nucleotide misincorporation types observed within modern and ancient datasets were obtain by the sum of the nucleotide misincorporation number revealed in each group of clones.
As shown in Figure 4, each dataset contains prediction and observed data for 4 days, and the three datasets are obtained by using a sliding window including 4 days, the sliding interval of which is set to half a day.
A list of sRNA datasets was obtained by querying from NCBI SRA database (http://www.ncbi.nlm.nih.gov/sra).nih.gov/sra
These representative datasets are obtained by choosing the dataset with the smallest euclidean distance between its own values and the optimum values obtained by all datasets on the Pareto front as described in Methods.
Very poor performance (recall of 0%% for 1 agonist dataset and 17 antagonist datasets), to very good performance (recall superior or equal to 90%% for 5 agonist datasets and MCC value superior to 0.8 for 3 agonist dataset) were obtained by screening the SB pharmacophores against the corresponding NRLiSt BDB datasets.
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