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Sequence datasets were downloaded and processed as described below.
Five datasets were downloaded and used in this study.
The leukocyte (GSE1133 & GSE22886), mouse AS (GSE41039) and patient biopsy (GSE41038) datasets were downloaded and processed independently [ 14– 17].
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As a first step in this process, raw.cel files from the AtGenExpress dataset were downloaded and analyzed for differential expression.
These datasets were downloaded on 10-12-2012 and segregated with respect to the stages in LUAD.
The Bhattacharya et al [10] and Wang et al [9] datasets were downloaded from GEO Omnibus (GSE8581 and GSE8500, repectively using array platforms, Affymetrix Human U133Plus 2.0 and Rosetta hu25k respectively).
Published WGBS datasets were downloaded from the EBI Read Archive and from GEO (ERR192350) and processed by the same analysis pipeline.
Briefly the raw datasets were downloaded from the NIH Human Epigenome Roadmap project and mapped and analyzed as described in Sati et al. (46).
These datasets were downloaded from public databases and the "Standalone WWW BLAST Server" from the National Center for Biotechnology Information (NCBI; ).
All amplicon datasets were downloaded from the Visualization and Analysis of Microbial Population Structures database (https://vamps.mbl.edu) and analyzed using the same methods as those applied on the SCS sample (i.e., using SILVA-ngs to generate OTUs and identify taxonomy; using Mothur to estimate diversity indices by resampling with 1000 iterations).
ChIP-Seq and RNA-Seq datasets were downloaded from ENCODE [ 20] for K562 and GM12878 cells.
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