Exact(8)
The randomized datasets were constructed using R version 3.1.1 [ 38].
Simulated datasets were constructed using EvolSimulator 2.1.0 [ 39].
First, partitioning datasets were constructed using the best-fit models.
Background sequences for these datasets were constructed using synthetic data, altering the probability of choosing each nucleotide to reflect the species GC-content as required.
Simulated datasets were constructed using a wide range of l and d parameters in order to compare the performance of different methods in dealing with various sizes of the motif and/or noisy situations.
Briefly, five large data collections each consisting of 1000 datasets were constructed using synthetic motifs of varying conservation and realistic E scherichia coli background sequence extracted from the EcoGene database (Rudd, 2000).
Similar(52)
Finally, a data collection consisting of nine datasets was constructed using known TFBS motif sequences from diverse prokaryotic species.
A sixth data collection consisting of 20 datasets was constructed using known E. coli TFBS sequences extracted from RegulonDB (Gama-Castro et al., 2011).
The two datasets are constructed using different scoring schemes on a same combined set of purification observations, therefore they can be used to test how different AP-MS scoring schemes affect the performance of the proposed model.
One thousand bootstrap pseudo-datasets were constructed using the program seqboot, which was used as input into ProML that used a Hidden Markov Model method to infer evolutionary rates among residue positions [38] with the Jones, Talyor, and Thorton [39] probability matrix.
In order to perform such an examination, a new dataset is constructed using previous results along with additional data retrieved from the Athens Stock Exchange website (http://www.ase.gr).gr
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