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The results obtained through three patient datasets were analysed by the consultant cardiologist from Raigmore Hospital.
> All three datasets were analysed by means of linear regressions.
The microarray and proteomics datasets were analysed by Gene Ontology (GO) [ 27] profiling using Fisher's exact test.
Differences between these two datasets were analysed by χ2 test using the R statistical package version 2.7.1.
For all marker systems the datasets were analysed by: 1) splitting the individuals into subsets according to taxa, 2) including all individuals, and 3) including only diploids.
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In addition, the dataset was analysed by Bayesian phylogenetic analysis using MrBayes 3.1.2 [ 36].
This dataset was analysed by a range of methods including the most recent ones; they are presented below, with their relative advantages and susceptibility to artefacts, and either using the amino-acid or the nucleotide sequence data, and in the last case, either using codon models, or nucleotide models with different partitions of codon positions.
The six datasets were analysed separately for association by TDT using the quality criteria mentioned.
Data sharing is not applicable to this paper as no datasets were analysed or generated.
Data sharing not applicable to this article as no datasets were analysed or generated.
Data sharing not applicable to this paper as no datasets were analysed or generated.
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