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However, many have observed that real-life datasets tend to have non-uniform distributions.
Zoonotic diseases are challenging to study from the ecological point of view as, broadly speaking, datasets tend to be either detailed on a small spatial extent, or coarse on a large spatial extent.
"The datasets tend to be extremely strict in their structure, and are usually too small.
The datasets tend to be biased towards drugs and targets that are considered to be more important or easier to test experimentally.
One might expect that artifactual datasets (such as ones with artificially flat or jagged landscapes) would allow one to draw general conclusions and indeed such artificially generated datasets tend to be consistently insignificant.
As Figure 2 indicates, the results from the exposures to the mixtures in the seven different datasets tend to fall into distinct groups reflecting the differences in the number and nature of the analytes investigated in each survey and the levels of contaminants in the waters being surveyed.
Similar(46)
For example, coarser maps (e.g. Gibbs & Brown, Drigo) were favored in the comparison because the similarity between the datasets tended to increase at lower resolution (see below).
We hypothesize that the ability of a signature to demonstrate predictive power across different independent datasets tends to support the conclusion that it is composed of key, biologically relevant genes.
In rice, the proportion of covered sites in genic regions was higher than in maize, the differences between the total predicted and covered datasets tended to be much smaller.
Notice, the relative performance of all three methods is on average the same, yet the SD in PDR and NDR, measured over all 10 000 simulated datasets, tends to be higher for BH than KBIN and TopK.
Then, we showed that the interaction neighbour proteins shared by the two lists of signature hubs from the two datasets tended to be cancer susceptibility genes and affect some pathways known to be associated with breast cancer pathogenesis, indicating that these pathways might have important diagnostic and therapeutic implications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com