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Functional echo-planar datasets sensitive to BOLD (Blood Oxygen Level Dependent) contrast were acquired at 1.5 Tesla (Siemens Sonata) The sequence, minimizing orbitofrontal signal dropout [55] achieved partial brain coverage (28 slices, 2 mm slice thickness, 1 mm gap, tilted −30° from inter-commissural plane, TR 2.52 seconds per volume, TE 40ms [see figure one]).
The low number of cell lines in the datasets sensitive to PHA665752 contributed to the difficulty of generating a predictive signature with good precision for this drug.
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Note that our study is still preliminary at this point since the matching range is dataset-sensitive and chosen manually in this paper.
"Datasets containing sensitive information about individuals clearly deserve more caution than others, and may not always be suitable for open public release".
Besides, the rate-hub correlation has been heterogeneous among different datasets, probably sensitive to various technical treatments [ 6].
Some datasets are sensitive to class imbalance but others are not, as shown by the difference between Acc and G -mean values.
In order to determine which functional categories were statistically more significant, we performed a different analysis of our datasets of sensitive and resistant strains using FUNSPEC (http://funspec.med.utoronto.ca/).utoronto.ca/
The cluster is enriched (FDR<0.05) for 125 GO categories, representing most enriched categories found in the entire dataset of sensitive strains.
Regarding the dataset of sensitive mutants, the most enriched terms were "mitochondrial translation" and "translation", evidencing the importance of protein synthesis in coping with both stresses.
The term "positive regulation of gluconeogenesis" (e.g., CAT8, GCR1, TDH1) also appeared significantly enriched in the dataset of sensitive mutant strains.
Of note, 5 of the 6 genes encoding the proteins from alpha-1,6-mannosyltransferase complex (ANP1, MNN9, MNN10, MNN11, and VAN1) were present in the dataset of sensitive mutants.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com