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Triple stores are capable of handling very large datasets of more than one billion triples [25], which continuously grows with new hardware and better optimized triple stores.
Next-generation high-throughput sequencers are capable of producing large datasets of more than a million reads from a single plate [5].
For large datasets of more than hundred millions of short reads, De Bruijn graph-based assemblers could have commendable resolutions due to their short runtime and low RAM occupancy, of which SOAPdenovo performs well on very short reads, while ALLPATHS-LG could be a good choice for ∼100 bp short reads assembly, as it was described [6].
For large datasets of more than hundred millions of short reads, De Bruijn graph-based assemblers would be more appropriate.
We find that datasets of more than 100 individual values can be used without decreasing the robustness of statistical analysis, and that independently generated random subsets of data have statistically indistinguishable global properties.
This mutation, absent from population surveys and public datasets of more than ten thousand complete mtDNAs (GenBank database was searched on March 2nd 2012), was previously detected in a patient with fatal infantile LS with bilateral brainstem lesions [7].
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