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So, datasets in hand, did Anderson's monkeys do the job?
This is feasible since the authors already have the ChIP-seq and RNA-seq datasets in hand.
With these ground truth datasets in hand, we evaluated clustering accuracy using the Jaccard coefficient as described by Tan et al. (2005).
Moreover, in order to perform comparative metagenomics using CAMERA, the datasets in hand must be traversed through the CAMERA pipeline, thus making integration of data from different resources more computationally demanding.
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This confirms that NSGWO performs significantly better than other methods for the real cervix lesion dataset in hand.
The first step of the DAN method consists of mapping the dataset in hand to a complex network.
In particular, the method maps the elements of the dataset in hand to a weighted network according to the similarity that holds among data.
Furthermore, one may note that a correlation often exists between the cardinality of the dataset in hand and the order of magnitude of its optimal λ (typically, the former and the latter have the same order of magnitude).
It is worth pointing out that the maximum value of log10 is expected to depend on the cardinality of the dataset in hand –the greater the cardinality, the greater the value of log10.
Then, one could improve the prediction model of BLUP|GA by building an S matrix with the top SNPs extracted from the dataset in hand according to their effect size as proposed in this study, the significance of association (de los Campos et al. 2013b), or from public sources as proposed in Kadarmideen (2014) and in our former study (Zhang et al. 2014).
Many population genetic programs, such as IMa (Hey and Nielsen, 2007), Structure (Pritchard et al., 2000) or Compute (Thornton, 2003) use multiple genes for analysis, however, preparation of such datasets, even with sequences in hand, is far from straightforward.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com