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For all datasets, details of taxon numbers, positions and models of sequence evolution are listed in Additional file 6.
We also ran all analyses and robustness checks using the Hooghe et al. data, and the results are consistent across these two datasets (details available from the authors).
In Canada with universal health insurance coverage, the health services are provided to all residents; therefore, almost all Canadians are represented by these datasets (details available from the Canada Health Care System website) [ 9].
The core ISA developers are engaged with an ever-growing number of collaborators: case studies from early implementers already provide evidence of the diverse life science scenarios in which the suite's various components have been successfully tested and are being used with large datasets (details on the ISA web site).
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We chose three multiclass microarray datasets (detailed described in the Datasets section) for our experiments.
To this end, we examined expression datasets detailing the relative abundance of a large number of human TFs across 40 normal and cancer cell types.
In all other respects except the ω distribution our set of 100 replicates was generated with the same parameters as the 5-taxon tree datasets detailed in Wong et al. [ 17].
From the datasets detailed in those studies, a subset of 11 overlapping landmarks, observable and with clear homology in both fissipeds and pinnipeds, and identifiable in all the fossils, was selected.
For Dependency Models, BHIT showed its remarkable capabilities in detecting multiple dependencies both in discrete and continuous datasets detailed in Table 2, while no other publicly available tools can handle these data.
This result is further corroborated by the results from stress expression datasets (detailed in a later section), suggesting that these retained duplicates might have contributed to the species-specific stress response in green algae.
Other information and dataset details are available from the corresponding author on reasonable request.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com