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The aggregation and curation of such datasets can be very exacting in terms of extraction of the data from the literature.
For the same biological condition, the gene signatures from different datasets can be very different.
Clustering of large datasets can be very difficult with the available clustering algorithms mainly due to the memory and time complexity.
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This makes weighted least squares useful for researchers interested in sample level (or by extension, population level) inferences because many standard statistical packages are not designed for choice models and require researchers to perform a certain amount of data manipulation; and datasets for individual level analyses can be very large, particularly in a best-worst context.
This type of classifier can be very accurate for very large datasets, if an appropriate measure of similarity is available.
These methods can be very effective when dealing with large datasets; however, they do not integrate with any external knowledge sources or inform the biology behind the interactions.
Based on a fixed-effects group analysis of null datasets (8 participants scanned while at rest), we show that the magnitude of the problem can be very substantial.
The method can be very useful for solving classification and clustering problems in which the training datasets are very large.
Young can be very, very young.
can be very helpful.
It can be very very harmful.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com