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Two datasets were defined in the analysis, namely, ingroup and outgroup, where the outgroup dataset included only M. sylvanus.

Volumes in these datasets are defined at a 1-mm isotropic voxel grid, with dimensions 217 × 181 × 181.

The volumes in these datasets are defined at a 1-mm isotropic voxel grid, with dimensions 256 × 256 × Z, where Z ranges from 55 to 67 with 3.1-mm slice thickness.

Genes with no AS variants identified in both datasets were defined as non-alternatively spliced genes.

To eliminate any possible biasness in the definition of "hub" and "end" proteins, we varied the cutoff values for "hub" proteins in two consecutive validation analyses and rather than defining a protein with more than 10 interactors as a "hub", those with more than 5 or 20 interactors in the disease datasets were defined as "hubs" respectively.

Genes with AS variants identified in both AltSplice and Ecgene datasets were defined as alternatively spliced genes.

Three datasets were defined for analysis.

The view angle of our dataset is defined as shown in Fig. 3.

Accuracy in this dataset was defined as the correlation between GEBV and simulated TBV in the validation set of the training stage or in the candidate set of the application stage, r = c o r (G E B V, T B V ).

A gene that is characteristic in any one of the PC1 3 in a given dataset is defined to be a characteristic gene for that dataset.

The overall likelihood in our dataset is defined as the average of the likelihood measured for each query, as follows: L(k) = frac{1}{| Z_{k} |} {displaystyle sum_{q in Z_{k}} L_{q} k)}.