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The growing number of gene expression datasets and availability of hundreds of bacterial genomes accelerated the quest for the construction of bacterial transcriptional regulatory networks (TRNs).
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The taxonomic groups targeted for the baseline reported here were determined primarily by the accessibility of datasets and the availability of authors with appropriate expertise and willingness to contribute data.
Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols.
The value of these things is the result of the ingenuity, competence and (perhaps above all) hard work of human beings, not something that follows automatically from the mere presence and availability of datasets over the web in a form which permits their reuse.
The limitation of the study was the laboratory validation of the targets and availability of datasets in the TCGA.
For MA datasets, which varied in the type and availability of information, we used a case-by-case approach utilizing all available information (see Additional file 1: Appendix B).
Further descriptions of the datasets discussed and the post-processing and availability of files are documented in Thorne et al. (2012).
In parallel, the structure of collaboration has attracted much attention, and collaboration networks have become a central example for the study of complex networks, thanks to the high quality and availability of the datasets [9].
A high level of microbial diversity and availability of metagenomic datasets obtained using various sequencing techniques make the human gut microbiome a promising object for studying CRISPR systems.
The generation and availability of consistent datasets from human and rodents representing a variety of perturbations carried out on the same tissue or cell types under identical conditions would be highly valuable to further our understanding and use of mouse and rat models as predictors for applications in biomedical research.
Contingent upon generation and availability of high quality datasets, whole genome tiling array transcriptomes and deep smRNA datasets such as for rice [85], [86] and other species will be suitable subjects for further computational methods testing and analysis.
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