Exact(1)
Although relative quantification methods are useful to compare the same proteins between multiple biological samples, they do not provide the possibility to directly compare the data with other datasets or compare different proteins within a dataset with each other and they, by definition, do not provide absolute quantitative data.
Similar(59)
More important is the ability to link diverse datasets with each other".
Particular focus on integration of high-throughput datasets with each other, and with phenotypic information and clinical outcomes.
More important is the ability to link diverse datasets with each other". It's about time we dropped the "big" jargon: "It's just data.
Being able to compare datasets with each other is tremendously valuable.
Instead of comparing whole GEO datasets with each other, we broke down each dataset into contrasts and used these as 'entities' for our analysis (Fig. 1).
These peer-to-peer networks allow the sharing of datasets directly with each other without the need for a central repository to provide the data hosting or bandwidth for downloading.
Pearson's correlation across cChIP-seq, Broad and SYDH confirmed that our method was highly reproducible (r = 0.96) and correlated with both ENCODE datasets (r = 0.86 with respect to Broad; r = 0.76 with respect to SYDH) as well as ENCODE datasets correlated with each other (r = 0.73) (Fig. 3a, Additional file 1: Figure S2b).
To visualize how genes in our dataset may interact with each other to influence development, we used IPA to generate a sublist of the up-regulated genes that are associated with neuronal development according to their Knowledgebase dataset.
As expected, the missing data for the seven variables of interest in our dataset were correlated with each other and with the outcome of interest, suggesting that the data are MAR or MNAR.
The LODD datasets are linked with each other, as well as with datasets provided by other Linked Data projects, such as Bio2RDF [22] and Chem2Bio2RDF [23], as well as primary data providers that offer their resources in RDF, such as UniProt [24, 25] and the Allen Brain Atlas [26].
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