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One comprehensive analytic dataset will be created for Aim 2 (external to the hospital) for the years 2005/2006 through 2012/2013.
Five to eight versions of the final analysis dataset will be created and analyzed using identical procedure, followed by combining the results so that variation between imputation versions is incorporated in the standard error and p-value.
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36 Ten imputed datasets will be created.
Analytic datasets will be created for the period between 2005/2006 and 2012/2013.
A total of 10 imputed datasets will be created, each analysed separately and the results averaged using Rubin's equations.
With regard to the DTI dataset, fractional anisotropy and mean diffusivity maps will be created using the Functional Magnetic Resonance Imaging of the Brain (FMRIB) diffusion toolbox in FMRIB Software Library FSLL) [ 53] by estimating diffusion tensors at each intracerebral voxel prior to using a b = 0 image for mapping into MNI standard space.
New variables will be created from the common core dataset, as required, in order to answer the research questions prospectively agreed by the EPOCH Collaborators.
Companies will be created.
Interaction terms will be created where necessary.
Ten imputed data sets will be created.
The templates will be created as follows.
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