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The first was the 60-patient Ma et al. dataset, which represents a group of early stage ER+ tamoxifen-treated patients [ 6].

The direction of sex-bias, if any, was obtained from the 'MetaClass' column of the dataset, which represents a concatenated list of sex-biased genes derived from multiple previous datasets.

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The resulting p-values are based on a summarization of all these 6 datasets, which represent a more confident evaluation of periodical expression than a single dataset.

The aggregation of the records stored in all the nodes builds a dataset which represents the vector x.

The traditional a priori knowledge such as shape and intensity distribution is always extracted from training dataset, which represents the commonness of object but cannot directly represent the individual characteristics of the current object in medical image.

The metaPCNA index is the median expression of the top 1% of genes that were most highly positively correlated with the proliferation marker proliferating cell nuclear antigen (PCNA) in the GSE2361 dataset, which represents gene expression profiles from 36 different normal human tissues [ 61].

For consensus of dataset which represented by ECFP_4 fingerprint, the best QPI values of consensus clustering are obtained from ensembles of size n = 20-50.

The completeness of the transcriptomic dataset was determined using the CEGMA tool, which represents a database of 458 highly conserved eukaryotic core genes present in a wide range of eukaryotic taxa [ 35].

The differences in mean scores between the two frailty indices from the same dataset were less than 0.02 in all datasets, which represents less than 1 deficit for NSHS and Yale-PEP and about 1.5 deficits for SHARE.

We used the most recent assembly (KH assembly) as the reference, which represents a haploid genome based on the US1 and US2 datasets.

IG9, which represents a basket of companies.

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