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The statistical descriptions for the case detectors in each dataset were compared and the results were found to be similar to those for the entire dataset.

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In relative protein quantitative analyses, multiple normalised global expression datasets were compared and contrasted.

The two datasets were compared and discrepancies resolved by checking with the original data.

Analyses using both the full and rarefied datasets were compared and, as the results did not differ, usually only those from the rarefied data are reported here.

The genomic locations of the peaks from our FIE-HA and H3K27me3 ChIP-seq datasets were compared and grouped into three categories; FIE-HA+H3K27me3, FIE-HA only and H3K27me3 only.

Mean values of continuous variables in the baseline socio-demographic and clinical dataset were compared between fallers and non-fallers using independent t-tests.

The ANN model and decision tree model of the two datasets (training dataset and test dataset) were compared in terms of mean absolute error and linear correlation coefficient in table 3.

The likelihood values of the different partitions of the dataset were compared via the Akaike Information Criterion (AIC) and the separation into 5 partitions (one each for 18S, 28S and 16S; COI separated in the two partitions 1st and 2nd position and 3rd position) improved the likelihood significantly (see Additional File 2).

17 To assess publication bias, effect sizes in the published, unpublished, and overall dataset were compared.

In the case of Tanjil, the extracted 16 conglutin consensus sequences from the RNAseq dataset were compared to the published NLL Tanjil sequences and these aligned very closely (99.6%-100%% identity).

All mature miRNA sequences represented by more than 3 reads within any of these datasets [ 39] were compared and transitively clustered into miRNA families defined through a pairwise Levenshtein distance ≤ 3. Directly using sequences rather than names allocated by authors avoids complications due to inconsistent naming conventions in the literature, of which we found several.

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