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The best GP model for the adenosine receptors dataset was obtained with the normalized polynomial (NP) kernel, exhibiting RMSEPext and R 0 ext 2 values of 0.58 p K i units and 0.75 respectively.
The clearest representation of the expression profiles within the dataset was obtained with a K = 10.
Additionally, there were difficulties with amplification of N13 in some individuals and, hence, a single dataset was obtained with 177 sequences of 336 bp.
The Q80 dataset was obtained with a different type of microarray than the other mouse datasets (Table 5), in which only about 50% of the genes were conserved and therefore Z-summary values were very low.
Data were collected from three crystals at NSRRC BL13C1 (Taiwan) and the final merged dataset was obtained with XDS [ 17] at a resolution of 2.7 Å (1 Å=0.1 nm).
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Data from the reference dataset were obtained with the Human Array-Ready Oligo set, version 2.0 (Qiagen) printed on Corning UltraGAPS slides, containing over 21,000 genes.
The profiles in the dataset were obtained with the Illumina Human v2 MicroRNA Expression BeadChips platform, were used as downloaded from the GEO repository, and included 1134 miRNA species after removing those with missing values.
Across the large spectra of core and CplusT lengths that were tested, the highest % phased in each of the datasets was obtained with relatively short core lengths and intermediate CplusT lengths (results not shown because the patterns were very similar to those for the simulated datasets).
We note that the maximum area in both datasets were obtained with the WP method (0.496 for dataset SR1 and 0.481 for SR2).
High-quality datasets were obtained with the highest peak around 10,000 counts as statistically required for proper quantitative XRD analysis [22 24].
Also here datasets were obtained with either a high IC or a low IC motif.
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