The authors would like to acknowledge Dr. Maxwell Lee and his collaborators for providing the dataset for the present study and for extensive comments on this manuscript.
Finally, using the same dataset as the present study, Rickard et al. [65], [66] have shown that offspring born after a brother have lower lifetime reproductive success than those born after a sister.
We also thank Jonathan J James, Stephen W Duffy, Olorunsola F Agbaje, Caroline RM Boggis and Susan M Astley for their contribution to the original study design, data collection and interpretation in the CADET II trial that provided the dataset for the present study.
The laboratory marker dataset of the present study was determined in 2008, 407 prevalent patients were recruited on a cross-sectional basis from 2008 to 2010, and the mortality registration was conducted from 2008 to 2013.
Evidently, the much larger dataset in the present study, which involved thousands of SNPs and a large population of families and offspring, enabled more reliable predictions of chromosomal rearrangements.
However, using the same dataset as the present study, we found lower risks of brain and spinal tumours among children born in areas of high population mixing, which was explained by a lower risk among children of incomers (Dickinson et al, 2002).
The unlinked dataset was internally linked by the DOH using stepwise deterministic linkage and person-identifying variables (such as sex, date of birth, country of birth, postcode, and Medicare number and suffix) to produce a linked dataset for the present study [ 22].
For consistency purposes with respect to the real-world datasets of the present study (but also to approximate the typical length of annual geophysical time series), the simulated time series are of 91 values as well.
