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All the processing steps were designed taking into account the low number of samples in the dataset, situation that is quite common in medical cases.
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This, apart from operating as the DR matrix, largely reduces the parameters and makes the proposed algorithm very suitable to small dataset situations.
Since the modules were identified independently of the expression datasets, situations occasionally arose in which some modules had missing gene expression values.
In large datasets the situation is the opposite.
The MIPEX results for 2004, 2007, and 2010 have been used by political scientists and sociologists as well as advocates and policymakers.2 The 2010 dataset covers the situation as of 1 June 2010 in the 27 EU Member States at the time, Norway, Switzerland, Canada, and the United States.
We took advantage of having a complete and accurate pedigree dataset available, a situation that is very rare in practice.
The Snow fall and Skating datasets reflect this situation.
Therefore, PACE analysis provides a statistical evaluation of small differences between just a few measured proteome datasets, in a situation where standard statistical methods fail.
In this study, however, we tried this dataset to mimic actual situation of the virtual screening after testing the methods on two well curated datasets.
It means that non-activity stop in our dataset does not include situation of traffic congestion which usually lasts for a long time.
To mimic the real world clinical situation, each dataset was divided into two sets, i.e., a training and validation set.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com