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Because these factors are only routinely measured in waitlisted candidates, they were largely missing in our dataset, rendering us unable to test our hypothesis in the entire ESRD population.
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Please note that these two resulting datasets both use the OSM wiki as their primary source, while combining the OSM wiki and the tag history into one dataset renders possible to relate the usage of tags in the OSM dataset and the documentation of the folksonomy (Table 1).
The few external validation studies done were performed in small datasets, rendering published results highly susceptible to sampling variability.
Sample images for these datasets are shown in Fig. 5. Fig. 5 Sample images from four synthesized datasets rendered with POV-Ray.
The large individual variability and the small dataset render conclusions difficult.
Such limited dataset renders it hard to differentiate between the following two scenarios: positive selection indeed occurred on evolutionary branches toward human/chimp; positive selection occurs on branches leading to other hominoids, e.g., orangutan and gibbon and thus signal observed by comparing human PIPSL and its two parental genes is a by-product.
The fact that these signatures are top performers, not only in terms of efficiency in classification but also regarding the informational content of the observed variation that they manage to explain in the integrative dataset, renders them ideal starting points for functional interpretation of critical determinants of the CM pathophysiological mechanism.
Possibly, an increased taxon sampling with a multi-locus dataset would render more precise age estimates and remove this remaining uncertainty.
However, the shear volume of these datasets renders manual analysis infeasible.
The concordance of allelic richness between the two types of loci occurred only transiently and at much higher values (∼9 alleles) than observed in our dataset (Figure 2), rendering this demographic scenario unlikely.
Therefore, we estimated phylogenies and molecular evolution parameters separately for each gene since concatenating both datasets would render inaccurate inferences as ISAV might exhibit reassortment between segments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com