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One potential is to use additional external datasets to help estimate gene expression levels and their differences for the dataset of the study.
We initially zoom onto miR-34a motivated by the study of Boon et al. [ 8] which named it as cardiac aging biomarker (the dataset of the study is used in our analysis).
The prospective subset (panel dataset) of the study is based on individuals who have had two health examinations 10 years apart and were not defined as having diabetes at their first health examination (n = 23,546).
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In the dataset of this study, the effect of the local morphology is evident (i.e., accumulations in front of scarps).
Cluster analysis, principal component analysis and factor analysis were used to better analyze the dataset of the studied variables.
The first stage includes the collection and cleaning of a dataset for the study and the selection of the best molecular representations [8 10].
Fig. 3 Workflow and datasets of the study.
The datasets of the study consisted of registry for beneficiaries, ambulatory and inpatient care claims, and Registry for Catastrophic Illness from 1996 to 2007 from NHIRD.
Cluster-level assignments will be under control of each country's lead data manager in separate data files that are independent from the main datasets of the study.
In total, we obtained 33 datasets containing 1327 microarrays, which is three times as large as that of 471 microarrays in the reference datasets of the study of Kim and Park (2004).
Microarray dataset for the study of chronic myeloid leukemia was obtained from Gene Expression Omnibus.
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