To determine the optimal value of k for a particular dataset one can take advantage of prior knowledge, as we did in the case of unigene/BAC assignment to chromosomes.
For field validation, we analyzed δ13C of individual grains of grass pollen from the surface sediments of 15 lakes in Africa and Australia, added these results to a prior dataset of 10 lakes from North America, and compared C4-pollen abundance in surface sediments with C4-grass abundance on the surrounding landscape.
In this study, we developed a scoring function for the identification of the active compounds in the AuPosSOM clustered dataset without prior knowledge of the compounds' activity.
We combined subsamples of different size (ranging from 5%to50%0% of the original dataset of 676 observations) with priors representing different levels of trust in legacy data and investigated the effect of sample size and prior distribution on map accuracy.
Thus, K-means pre-sorting of datasets prior to network construction appears to have a positive effect on capture of unique biological function.
Bayesian clustering analysis as implemented by STRUCTURE 2.2 [ 23] was used to infer population substructure/ancestry from the dataset without prior information of sampling groups (i.e. phenotypes), under the admixture model with correlated allele frequencies.
The BaMBA curation team, checks the geographic coordinates of datasets prior to deposition, to certify that they belong to marine environments.
Through aggregation of data for genetic variants across pedigree members, VASP allows powerful, custom variation prioritization, taking advantage of external datasets and prior knowledge of disease incidence and inheritance patterns.
The most remarkable observation is that a calibration based on combined datasets results in the lowest effect of prior analytical decisions on both evolutionary rate and node age estimation, together with a reduction of 95% HPD intervals associated to these estimates.
To avoid overfitting the model, any samples included in a dataset of interest should be removed prior to estimation of the hyperparameters.
