To assess significance, we compared our observed t-statistic to t-statistics from 104 bootstrapped datasets of comparable sizes (sampled with replacement).
To probe the chromatin features of EIs, we compared locations of EIs in H1, HAEC and HPF with public datasets of comparable cell lines [ 10, 23].
Two publicly available non-subtype specific primary breast cancer datasets of comparable size and composition (Nadiri et al.[ 26] n = 153 on Illumina WG6v1 and Desmedt et al.[ 27] n = 198 on Affymetrix HGU133A) were assigned to molecular subtypes using centroids from the intrinsic gene signatures of Sorlie et al. (2003) [ 5], Parker et al.[ 28], and Hu et al. [ 29].
For comparison, the positive correlation observed between clinical PR status and array determined PR transcript levels from this same dataset was of comparable, albeit slightly greater, magnitude (rp = +0.24; P = 9.033 × e-07).
For synthetic datasets of sizes comparable to our real data size, do we recover known ground truth information after running our Markov chains for the appropriate amount of time?
The CRW datasets were chosen for analysis because they have highly reliable curated alignments based on secondary and higher order structure; to our knowledge, there are no larger biological datasets with alignments of comparable reliability.
The calculated root mean square deviation between calculated and experimental pH stability optima is 0.78 for the dataset of 19 enzymes, comparable with the value of 0.72 for the earlier work [ 31], and supporting the use of Debye-Hückel modelling in this study.
A statistical treatment of the populations of mRNAs undergoing variations in our collection of comparable dataset pairs provides the falsification of a model of straight dependency between translatome changes from transcriptome changes.
Likewise, the test of the predictive hazard equations (that include cohort factors) on an independent data set could not be implemented due to the lack of dataset with comparable cohort information or adequate structure that would minimize the risk of confounding between factors.
External validation was not possible given the lack of comparable datasets in multiple myeloma in which all three questionnaires were administered.
