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Although this question deserves further investigation, using a well-designed dataset, implementing sex-specific analyses is not possible in situations in which the number of progeny of each sex is small and the data structure does not permit adequate estimation of effects at the level of residual variance.
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The robustness of the resulting tree was assessed by the non-parametric bootstrap method (100 replicates of the original dataset) implemented in SeaView.
Tatiana Tatarinova curated the datasets, implemented the algorithm, carried out the comparison of algorithms, and wrote the paper.
Consequently, ConTra's processing time can be improved to process very large dataset by implementing its algorithm on a parallel processor environment.
The large number of sequenced genomes and the diversity in their evolutionary distances make this an ideal dataset for implementing phylogenetic footprinting techniques.
Therefore, before running FPC to construct the contigs, we removed the likely contaminated BACs in the dataset by implementing a de-contamination function in FPC.
We use Algorithm 1 to generate the dataset, which implements a numerical solution of the IK.
A phylogeny of the concatenated dataset was implemented in MrBayes.
We used a GTR+I+G model of evolution on an un-partitioned dataset, and implemented an uncorrelated lognormal relaxed molecular clock method [ 14].
Using the SNP data from version 3.05 of the Nordborg dataset, we implemented the MTMM described by Korte et al. (2012) to perform the association analyses.
For each dataset, we implement 5-fold cross validation and repeat it 10 times to reduce the fluctuation due to chance of divisions of the data.
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