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The robustness of the resulting tree was assessed by the non-parametric bootstrap method (100 replicates of the original dataset) implemented in SeaView.

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A phylogeny of the concatenated dataset was implemented in MrBayes.

We used the Markov Chain Monte Carlo method (8), which assumes multivariate normality to impute all missing values to make 10 complete datasets, as implemented in SAS Proc MI.

Also, two good nominates [12,32] of the previous works under our conditions (e.g., the same datasets) should be implemented in order to compare their performance with ours.

This methodology was specifically developed to model short time-series datasets and is implemented in tigre, R package [ 17].

ML analyses were performed in PAUP* with the nucleotide substitution model and specific parameters selected for each dataset using ModelTest as implemented in PAUP* [86].

We generated lower and upper estimates of circumcision frequency in urban male adults of each ethnic group, based on the method explained in Text S2 and implemented in Dataset S1.

Additional data analysis was done for the prefrontal cortex dataset using the GLM implemented in edgeR (version 3.2.3) and the Voom transformation found in Limma (version 3.16.5).

This paper introduces a file format for exchanging QSAR datasets, together with tools implemented in the graphical workbench Bioclipse [23, 24] to facilitate working with QSAR according to the standard.

Maximum-likelihood (ML) phylogenetic trees were estimated for both datasets using the method implemented in the PAUP* package (8 ).

We first performed phylogenetic dating on all our dataset employing a bayesian algorithm implemented in BEAST [ 58].

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