Mutually exclusive inactivation of MAP3K1 and MAP2K4 was confirmed in the Ellis et al. [ 11] dataset, corroborating the hypothesis of reduced JNK signaling in Luminal A tumors and providing further insights into MAP3K1 mutations.
Examination of additional, independent, cancer datasets corroborated our observations.
Quantitation of the histological and MR datasets corroborated our qualitative observations.
The numeric data presented in the pathway-specific discussions is primarily from the unassembled datasets, as the assembled datasets corroborated the results from the unassembled data.
Identification of imbalanced alleles in most of the known imprinted genes within our dataset further corroborates the utility of RNA-seq in characterization of AI. * Chi-squared p < 0.01 difference from 50 50 expression of both alleles.
To support the use of DEA for distribution efficiency measurement, an optimisation technique was applied to the same dataset to corroborate the DEA results.
These genes not only show a consistent up-regulation in in vivo pulmonary inflammation studies, but also a clear overlap with genes found to be induced in vitro [1] [4] (Supporting Dataset S1), corroborating the pivotal role these genes play in response to a wide range of agents.
The findings from this expanded dataset firmly corroborate the importance of gene signature based classification in categorizing glioblastomas into prognostically meaningful molecular groups.
Another study implemented phylogenetic inference of 128 protein-coding orthologs of the myxosporean Myxobolus cerebralis alongside B. plumatellae within a broad, metazoan dataset, firmly corroborating the cnidarian origin of the Myxozoa [ 10].
Two mutual information-based approaches, the 'algorithm for the reconstruction of accurate cellular networks' (ARACNe) (Margolin et al., 2006) and the 'context likelihood of relatedness' (CLR) (Faith et al., 2007), were also applied to the same dataset to corroborate the results.
