Exact(1)
Excision resulted in a 422 amino acid dataset centered on the seven transmembrane domains and the intervening intra- and extracellular domains.
Similar(7)
> -wrap-foot> > -wrap-foot> To visualize the results of PARADIGM inference, we developed a 'CircleMap' visualization to display multiple datasets centered around each gene in a pathway (Fig. 7).
In brief, for each gene common to the Hoadley platform and the other breast-array dataset platform, we computed the mean centroid of the luminal A and B subtypes in the Hoadley dataset and centered each group average on the centroid.
In the case of the PAM50 signature, the UNC dataset was centered probe-wise prior to establishment of the centroids for the subtypes.
The expression levels of adiponectin mRNA in each skin biopsy were extracted from this dataset and centered on its mean value across all arrays.
In brief, the PI3K mRNA t score was defined as the two-sided t statistic comparing the average of the PI3K-induced genes with that of the repressed genes within each tumor (after first centering the log-transformed values on the median across samples; Loi dataset: values centered to standard deviations from the median within U133A and U133Plus2 array subsets).
Gene expression values in the clinical breast tumor and cell line profile datasets were centered on the centroid mean of ER- and ER+.
The p63BS datasets were centered on the peak summit of the identified p63 peaks (Supplementary Table S5) and extended 300 bp to both directions.
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Justyna Jupowicz-Kozak
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