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The bait sequence from FlyBase was used to perform a similarity search using blastp [ 69] of non-redundant protein databases curated by uniprot http://www.uniprot.org/.org/
The enrichment analysis was applied to the Gene Ontology (GO) terms Biological Process (BP), Molecular Function (MF), and Cellular Component (CC), and to pathway databases curated by KEGG, Reactome and Biocarta, by using the DAVID web resource [ 37, 38].
The database combines data from a variety of sources, including several miRNA target prediction databases, curated literature of experimentally validated miRNA target genes and published gene drug interactions as annotated by PharmGKB or in the VerSe database that accompanies the web server.
With emphases on curating modification data from large-scale tandem mass spectrometry (MS/MS) experiments and providing in-depth online analysis engines for PTM proteins, our work SysPTM (17) was developed as a comprehensive resource integrated with existing features of numerous external databases, curated MS/MS data and four analysis tools (PTMBlast, PTMPathway, PTMPhylog, PTMCluster).
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On average, two databases curating the same publication agree on 42% of their interactions.
It also serves as a general model for disease-driven databases curating phenotypic characteristics of corresponding animal models.
As a starting point, we have focused our study on two specific databases curating microarray and protein-related data: GEO and PDB.
Turinsky et al. (24) recently observed that this different representation of complexes is responsible for a significant number of disagreements between major databases curating the same publication.
PPI network was constructed based on the protein interaction information retrieved from STRING Search Tooll for the Retrieval of Interacting Genes/Proteins, http://string-db.org/ 12, an online protein-protein interaction database curated from literature and predicted associations from systemic genome comparisons.
These "counts" are recorded by each count circle's leader and added to a massive database curated by the National Audubon Society.
What would be needed is a ground truth crime database curated by hand to ensure that mislabeling of official crime types is kept to a minimum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com