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For calculations, drug target pairs that were only represented once in the database were not considered.
For both MS and MS/MS, MASCOT scores falling below the 95% certainty criterion for the respective database were not considered significant.
To avoid the possibility of sequencing errors in the EST database, the matches that were identified only once among the EST database were not considered.
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The main difference to this study is that persistence to database was not considered in their study.
The Path2Models branch of BioModels Database is not considered to be a frozen resource, and improved versions will be released as they are made available.
Those variants, which do not cause any amino acid change and already reported as polymorphisms in databases, were not considered to be significant and were excluded from further analysis (data not shown).
Korean trials indexed in English-based databases were not considered.
Possible influences of different blast programs and the size of databases were not considered in setting the above E-value thresholds.
From the literature search, we found that there were substantial numbers of clinical trials on acupuncture in Korean literature, even though Korean trials indexed in English-based databases were not considered.
Furthermore, if the details on the consent form did not match those on the Medicare enrolment database (e.g. the supplied name did not match the name corresponding to the Medicare number on the database) they were not considered for linkage.
First, although we included a variety of commonly used chemical databases, the number of databases is not very large and our results may not apply to databases that were not considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com