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Sequence homologies to genes in the GenBank database were determined by using the BLAST algorithm of the National Center for Biotechnology Information at the National Library of Medicine.
CENP-A-enriched centromeric sequence features (50-mer database) were determined by taking the log transformed normalized ratio of the frequency within the CENP-A relative to the genomic database.
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The selection of the following database was determined by its availability.
The number of genome equivalents in each microbial sample included in the Global Ocean Sampling series in the CAMERA database was determined by BLASTX searching each sample using the Escherichia coli recA gene as a query.
The database is determined by estimation of a set of parameters representing species-level free energies of formation.
Localization of enzymes present in the database was determined by submitting the amino acid sequence to software programs [ 20, 21] which identify the presence or absence of a signal peptide (SP).
The relatedness of isolates and known similar strains in the database was determined by constructing a neighbor-joining tree using a program online, Draw Tree Using Own MLST Data, found at the pneumococcal MLST website.
Expressed loci in each of the large non-Arabidopsis EST databases were determined by comparison of BLASTX alignments of EST contigs and singlets with their best match Arabidopsis MST protein.
§Comparisons of translated query versus protein databases was determined by using BLASTX 2.2.21 (www.ncbi.nlm.nih.gov/blast/Blast.cgi).nih.gov/blast/Blast.cgi
Significance of A-to-I editing site and MAID occurrence in human cDNA databases was determined by chi-square distribution test.
Real database identifications were determined by comparison of the real and decoy database matches using our DecoyPepFilter program.
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