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For each set, the small molecules existing in the reference library were firstly removed, and the sequences were mapped onto DRTs by similarity searching against the local BLAST database mentioned above.
Subsequently the overlap of the two datasets was calculated using the database mentioned above.
Proteios was used to identify hits at an estimated peptide spectrum match false discovery rate (FDR) of 0.01 using the random database mentioned above.
Therefore, we identified H. glycines proteins that showed significant sequence similarity with microbe or plant proteins by manually sorting the results of the BLASTX searches of all 6,860 H. glycines genes against the non-redundant GenBank database mentioned above.
The isobaric tags for relative and absolute quantitation (iTRAQ) data by Parker et al. were searched using the database mentioned above in order to generate information about total protein level changes (Supplementary Table S1).
Homology among BAC clones from the same X/Y probe gene pair was assessed by aligning the BAC sequences with MAUVE 2.3.1 [ 32] after masking the repeats using RepeatMasker v3.3.0 (http://www.repeatmasker.org/) with the Silene DNA repeat database mentioned above.
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All the modalities of the proposed database are extracted using only a single sensor while the other databases mentioned above used multiple sensors.
Of the three disaster databases mentioned above, EM-DAT is the only publicly available database that provides country/region-level disaster data (Guha-Sapir and Below 2002).
None of the resistance databases mentioned above provide an automated prediction tool to study structural changes leading to drug resistance caused by mutations in human kinases.
All the sequences were annotated according to their best BLAST hit against any of the databases mentioned above.
For those miRNAs (clustered on Xq27.3) without target recorded in the two databases mentioned above, we only retained those putative targets uniformly predicted by miRanda and miRmap 2.0.
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